Tolerance and Persistence of Ebola Virus in Primary Cells from <i>Mops condylurus</i>, a Potential Ebola Virus Reservoir.

ABSTRACT: Although there have been documented Ebola virus disease outbreaks for more than 40 years, the natural reservoir host has not been identified. Recent studies provide evidence that the Angolan free-tailed bat (Mops condylurus), an insectivorous microbat, is a possible ebolavirus reservoir. To investigate the potential role of this bat species in the ecology of ebolaviruses, replication, tolerance, and persistence of Ebola virus (EBOV) were investigated in 10 different primary bat cell isolates from M. condylurus. Varying EBOV replication kinetics corresponded to the expression levels of the integral membrane protein NPC1. All primary cells were highly tolerant to EBOV infection without cytopathic effects. The observed persistent EBOV infection for 150 days in lung primary cells

SUBMITTER: Bokelmann M 

PROVIDER: S-EPMC8622823 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature