Interactions between Polygenic Risk Scores, Dietary Pattern, and Menarche Age with the Obesity Risk in a Large Hospital-Based Cohort.

ABSTRACT: Obese Asians are more susceptible to metabolic diseases than obese Caucasians of the same body mass index (BMI). We hypothesized that the genetic variants associated with obesity risk interact with the lifestyles of middle-aged and elderly adults, possibly allowing the development of personalized interventions based on genotype. We aimed to examine this hypothesis in a large city hospital-based cohort in Korea. The participants with cancers, thyroid diseases, chronic kidney disease, or brain-related diseases were excluded. The participants were divided into case and control according to their BMI: ≥25 kg/m² (case; n = 17,545) and <25 kg/m² (control; n = 36,283). The genetic variants that affected obesity risk were selected using a genome-wide association

SUBMITTER: Park S 

PROVIDER: S-EPMC8622855 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature