Differential Responses of Neural Retina Progenitor Populations to Chronic Hyperglycemia.

ABSTRACT: Diabetic retinopathy is a frequent complication of longstanding diabetes, which comprises a complex interplay of microvascular abnormalities and neurodegeneration. Zebrafish harboring a homozygous mutation in the pancreatic transcription factor pdx1 display a diabetic phenotype with survival into adulthood, and are therefore uniquely suitable among zebrafish models for studying pathologies associated with persistent diabetic conditions. We have previously shown that, starting at three months of age, pdx1 mutants exhibit not only vascular but also neuro-retinal pathologies manifesting as photoreceptor dysfunction and loss, similar to human diabetic retinopathy. Here, we further characterize injury and regenerative responses and examine the effects on progenitor cell population

SUBMITTER: Schmitner N 

PROVIDER: S-EPMC8622914 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature