Safety and Efficacy of the East Coast Fever Muguga Cocktail Vaccine: A Systematic Review.

ABSTRACT: Immunisation of livestock with high quality vaccines is considered an essential approach to controlling many animal diseases. The only currently available commercial vaccine to protect cattle from East Coast fever (ECF), a tick-borne disease caused by Theileria parva, is an unconventional "infection and treatment method" (ITM) involving administration of a combination of live T. parva isolates, referred to as the "Muguga cocktail", and simultaneous treatment with long-acting oxytetracycline. Veterinary vaccine research and development typically involves studies designed to demonstrate vaccine quality, safety, and efficacy; however, as there were no such purpose-designed registration studies conducted for the Muguga cocktail, evidence for safety and efficacy is solely based on that which is

SUBMITTER: Allan FK 

PROVIDER: S-EPMC8623010 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature