Gene Therapeutic Approaches for the Treatment of Mitochondrial Dysfunction in Parkinson's Disease.

ABSTRACT: Mitochondrial dysfunction has been identified as a pathophysiological hallmark of disease onset and progression in patients with Parkinsonian disorders. Besides the overall emergence of gene therapies in treating these patients, this highly relevant molecular concept has not yet been defined as a target for gene therapeutic approaches. This narrative review will discuss the experimental evidence suggesting mitochondrial dysfunction as a viable treatment target in patients with monogenic and idiopathic Parkinson's disease. In addition, we will focus on general treatment strategies and crucial challenges which need to be overcome. Our current understanding of mitochondrial biology in parkinsonian disorders opens up the avenue for viable treatment strategies in Parkinsonian disorders. Insight

SUBMITTER: Prasuhn J 

PROVIDER: S-EPMC8623067 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature