High Individual Heterogeneity of Neutralizing Activities against the Original Strain and Nine Different Variants of SARS-CoV-2.

ABSTRACT:

Background

Since the beginning of the COVID-19 pandemic, several SARS-CoV-2 variants have sequentially emerged. In France, most cases were due to spike D641G-harbouring viruses that descended initially from the Wuhan strain, then by the variant of B.1.160 lineage we called Marseille-4 since the summer of 2020, which was followed by the Alpha and Beta variants in early 2021, then the Delta variant currently.

Methods

We determined the neutralising antibody (nAb) titres in sera from convalescent individuals previously infected by these four major local variants and from vaccine recipients to the original Wuhan strain and nine variants, including two recent circulating Delta isolates.

Results

The results show high inter-individual heterogeneity in nAbs, especially accordi

SUBMITTER: Jaafar R 

PROVIDER: S-EPMC8623169 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature