Impact of O-Acetylation on S. flexneri 1b and 2a O-Antigen Immunogenicity in Mice.

ABSTRACT: Shigellosis is a diarrheal disease caused prevalently by Shigella flexneri and S. sonnei and representing a major global health risk, particularly in developing countries. Bacterial O-antigen (OAg) is the primary target of the host immune response and modifications of its oligosaccharide units, including O-acetylation, are responsible for the variability among the circulating S. flexneri serotypes. No vaccines are widely available against shigellosis and the understanding of the immunogenicity induced by the OAg is fundamental for the design of a vaccine that could cover the most prevalent Shigella serotypes. To understand whether a different O-acetylation pattern could influence the immune response elicited by S. flexneri OAg, we employed as a vaccine technology GMMA purified from S. flex

SUBMITTER: Arato V 

PROVIDER: S-EPMC8623282 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature