Statins and Bempedoic Acid: Different Actions of Cholesterol Inhibitors on Macrophage Activation.

ABSTRACT: Statins represent the most prescribed class of drugs for the treatment of hypercholesterolemia. Effects that go beyond lipid-lowering actions have been suggested to contribute to their beneficial pharmacological properties. Whether and how statins act on macrophages has been a matter of debate. In the present study, we aimed at characterizing the impact of statins on macrophage polarization and comparing these to the effects of bempedoic acid, a recently registered drug for the treatment of hypercholesterolemia, which has been suggested to have a similar beneficial profile but fewer side effects. Treatment of primary murine macrophages with two different statins, i.e., simvastatin and cerivastatin, impaired phagocytotic activity and, concurrently, enhanced pro-inflammatory responses upon s

SUBMITTER: Linnenberger R 

PROVIDER: S-EPMC8623589 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature