Sphingomonas and Phenylobacterium as Major Microbiota in Thymic Epithelial Tumors.

ABSTRACT: The microbiota has been reported to be closely associated with carcinogenesis and cancer progression. However, its involvement in the pathology of thymoma remains unknown. In this study, we aimed to identify thymoma-specific microbiota using resected thymoma samples. Nineteen thymoma tissue samples were analyzed through polymerase chain reaction amplification and 16S rRNA gene sequencing. The subjects were grouped according to histology, driver mutation status in the GTF2I gene, PD-L1 status, and smoking habits. To identify the taxa composition of each sample, the operational taxonomic units (OTUs) were classified on the effective tags with 97% identity. The Shannon Index of the 97% identity OTUs was calculated to evaluate the alpha diversity. The linear discriminant analysis effect size (

SUBMITTER: Higuchi R 

PROVIDER: S-EPMC8623653 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature