Radiolabeled Silicon-Rhodamines as Bimodal PET/SPECT-NIR Imaging Agents.

ABSTRACT: Radiolabeled fluorescent dyes are decisive for bimodal imaging as well as highly in demand for nuclear- and optical imaging. Silicon-rhodamines (SiRs) show unique near-infrared (NIR) optical properties, large quantum yields and extinction coefficients as well as high photostability. Here, we describe the synthesis, characterization and radiolabeling of novel NIR absorbing and emitting fluorophores from the silicon-rhodamine family for use in optical imaging (OI) combined with positron emission tomography (PET) or single photon emission computed tomography (SPECT), respectively. The presented photostable SiRs were characterized using NMR-, UV-Vis-NIR-spectroscopy and mass spectrometry. Moreover, the radiolabeling conditions using fluorine-18 or iodine-123 were extensively explored. After op

SUBMITTER: Kanagasundaram T 

PROVIDER: S-EPMC8623702 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature