Effect of Quercetin on Injury to Indomethacin-Treated Human Embryonic Kidney 293 Cells.

ABSTRACT: Nonsteroidal anti-inflammatory drugs (NSAIDs) are used to treat inflammation and pain and even to prevent the progression of cardiovascular disease. They have become widely used because of their effectiveness, especially among athletes performing high-intensity training. Indomethacin is used for pain management in sports medicine and is highly effective and versatile. However, several clinical studies have reported that indomethacin induces acute renal damage. In the present study, we determined that indomethacin reduced human embryonic kidney 293 (HEK293) cell viability in a concentration-dependent manner by triggering apoptosis. In addition, we demonstrated the effect of quercetin on indomethacin-treated HEK293 cells by inactivating the caspase-3 and caspase-9 signals. Furthermore, querc

SUBMITTER: Chen C 

PROVIDER: S-EPMC8623736 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature