Genetic Variability of the Functional Domains of Chromodomains Helicase DNA-Binding (CHD) Proteins.

ABSTRACT: In the past few years, there has been an increasing neuroscientific interest in understanding the function of mammalian chromodomains helicase DNA-binding (CHD) proteins due to their association with severe developmental syndromes. Mammalian CHDs include nine members (CHD1 to CHD9), grouped into subfamilies according to the presence of specific functional domains, generally highly conserved in evolutionary terms. Mutations affecting these domains hold great potential to disrupt protein function, leading to meaningful pathogenic scenarios, such as embryonic defects incompatible with life. Here, we analysed the evolution of CHD proteins by performing a comparative study of the functional domains of CHD proteins between orthologous and paralogous protein sequences. Our findings show that the

SUBMITTER: Cardoso AR 

PROVIDER: S-EPMC8623811 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature