Endothelial Dysfunction through Oxidatively Generated Epigenetic Mark in Respiratory Viral Infections.

ABSTRACT: The bronchial vascular endothelial network plays important roles in pulmonary pathology during respiratory viral infections, including respiratory syncytial virus (RSV), influenza A(H1N1) and importantly SARS-Cov-2. All of these infections can be severe and even lethal in patients with underlying risk factors.A major obstacle in disease prevention is the lack of appropriate efficacious vaccine(s) due to continuous changes in the encoding capacity of the viral genome, exuberant responsiveness of the host immune system and lack of effective antiviral drugs. Current management of these severe respiratory viral infections is limited to supportive clinical care. The primary cause of morbidity and mortality is respiratory failure, partially due to endothelial pulmonary complications, including e

SUBMITTER: Vlahopoulos S 

PROVIDER: S-EPMC8623825 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature