Enantioselectivity of Chiral Derivatives of Xanthones in Virulence Effects of Resistant Bacteria.

ABSTRACT: Antimicrobial peptides are one of the lines of defense produced by several hosts in response to bacterial infections. Inspired by them and recent discoveries of xanthones as bacterial efflux pump inhibitors, chiral amides with a xanthone scaffold were planned to be potential antimicrobial adjuvants. The chiral derivatives of xanthones were obtained by peptide coupling reactions between suitable xanthones with enantiomerically pure building blocks, yielding derivatives with high enantiomeric purity. Among 18 compounds investigated for their antimicrobial activity against reference strains of bacteria and fungi, antibacterial activity for the tested strains was not found. Selected compounds were also evaluated for their potential to inhibit bacterial efflux pumps. Compound (R,R<

SUBMITTER: Duraes F 

PROVIDER: S-EPMC8623869 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature