Transdermal Delivery of Macromolecules Using Two-in-One Nanocomposite Device for Skin Electroporation.

ABSTRACT: Delivery of hydrophilic molecules through the skin using electroporation is a promising alternative approach to intradermal injection. Recently, we developed a two-in-one electrode/reservoir material composed of carbon nanotubes and agarose hydrogel. In this work, we evaluated the potential of the device to achieve non-invasive transdermal drug delivery using skin electroporation. As it involved an electrode configuration different from the literature, critical questions were raised. First, we demonstrated the efficiency of the device to permeabilize the skin of hairless mice, as observed by propidium iodide (PI) uptake in the nuclei of the epidermis cells through macro fluorescence imaging and histology. Application of Lucifer yellow (LY) at different times after unipolar electroporation

SUBMITTER: Simon J 

PROVIDER: S-EPMC8624044 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature