Plasma Metabolomics of Intermediate and Neovascular Age-Related Macular Degeneration Patients.

ABSTRACT: To characterize metabolites and metabolic pathways altered in intermediate and neovascular age-related macular degeneration (IAMD and NVAMD), high resolution untargeted metabolomics was performed via liquid chromatography-mass spectrometry on plasma samples obtained from 91 IAMD patients, 100 NVAMD patients, and 195 controls. Plasma metabolite levels were compared between: AMD patients and controls, IAMD patients and controls, and NVAMD and IAMD patients. Partial least-squares discriminant analysis and linear regression were used to identify discriminatory metabolites. Pathway analysis was performed to determine metabolic pathways altered in AMD. Among the comparisons, we identified 435 unique discriminatory metabolic features. Using computational methods and tandem mass spectrometry, we i

SUBMITTER: Mitchell SL 

PROVIDER: S-EPMC8624113 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature