Novel Chitosan-Silica Hybrid Hydrogels for Cell Encapsulation and Drug Delivery.

ABSTRACT: Hydrogels constructed from naturally derived polymers provide an aqueous environment that encourages cell growth, however, mechanical properties are poor and degradation can be difficult to predict. Whilst, synthetic hydrogels exhibit some improved mechanical properties, these materials lack biochemical cues for cells growing and have limited biodegradation. To produce hydrogels that support 3D cell cultures to form tissue mimics, materials must exhibit appropriate biological and mechanical properties. In this study, novel organic-inorganic hybrid hydrogels based on chitosan and silica were prepared using the sol-gel technique. The chemical, physical and biological properties of the hydrogels were assessed. Statistical analysis was performed using One-Way ANOVAs and independent-sample t-te

SUBMITTER: Jayash SN 

PROVIDER: S-EPMC8624171 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature