Ontology highlight
ABSTRACT:
SUBMITTER: Benedetti F
PROVIDER: S-EPMC8624325 | biostudies-literature | 2021 Oct
REPOSITORIES: biostudies-literature
Benedetti Filippo F Stadlbauer Katharina K Stadlmayr Gerhard G Rüker Florian F Wozniak-Knopp Gordana G
Life (Basel, Switzerland) 20211029 11
The overexpression of tyrosine kinase HER2 in numerous cancers, connected with fierce signaling and uncontrolled proliferation, makes it a suitable target for immunotherapy. The acquisition of resistance to currently used compounds and the multiplicity of signaling pathways involved prompted research into the discovery of novel binders as well as treatment options with multiple targeting and multispecific agents. Here we constructed an anti-HER2 tetravalent and biparatopic symmetrical IgG-like m ...[more]