Evaluation of Gallic Acid-Coated Gold Nanoparticles as an Anti-Aging Ingredient.

ABSTRACT: Hyperglycemic environment-induced oxidative stress-mediated matrix metalloproteinase-1 (MMP-1) plays a crucial role in the degradation of the extracellular matrix (ECM), which might contribute to premature skin aging. Synthesized, environmentally friendly gallic acid-coated gold nanoparticles (GA-AuNPs) have been evaluated as an anti-aging antioxidant. Their microstructure was characterized by transmission electron microscopy (TEM), which showed that GA-AuNPs are spherical when prepared at pH 11. Dynamic light scattering (DLS) analysis revealed that the average hydrodynamic diameter of a GA-AuNP is approximately 40 nm and with a zeta potential of -49.63 ± 2.11 mV. Additionally, the present data showed that GA-AuNPs have a superior ability to inhibit high glucose-mediated MMP-1-elicited typ

SUBMITTER: Wu YZ 

PROVIDER: S-EPMC8624563 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature