Xanthohumol Is a Potent Pan-Inhibitor of Coronaviruses Targeting Main Protease.

ABSTRACT: Coronaviruses cause diseases in humans and livestock. The SARS-CoV-2 is infecting millions of human beings, with high morbidity and mortality worldwide. The main protease (M^pro) of coronavirus plays a pivotal role in viral replication and transcription, which, in theory, is an attractive drug target for antiviral drug development. It has been extensively discussed whether Xanthohumol is able to help COVID-19 patients. Here, we report that Xanthohumol, a small molecule in clinical trials from hops (Humulus lupulus), was a potent pan-inhibitor for various coronaviruses by targeting M^pro, for example, betacoronavirus SARS-CoV-2 (IC₅₀ value of 1.53 μM), and alphacoronavirus PEDV (IC₅₀ value of 7.51 μM). Xanthohumol inhibited M^pro ac

SUBMITTER: Lin Y 

PROVIDER: S-EPMC8624673 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature