Probiotics Improve Gastrointestinal Function and Life Quality in Pregnancy.

ABSTRACT: We studied whether probiotics were beneficial for hormonal change-associated dysbiosis, which may influence the enteric nervous system and GI function during early pregnancy. The study was 16 days consisting of two cycles of six daily probiotics mainly Lactobacillus and 2 days without probiotics. Daily surveys were conducted to monitor GI function and life quality. A subset of the participants who contributed fecal specimens was used for microbiota metagenomic sequencing, metabolomics, and quantification of bacterial genes to understand potential underlying mechanisms. Statistical analyses were done by generalized linear mixed-effects models. Thirty-two obstetric patients and 535 daily observations were included. The data revealed that probiotic supplementation significantly reduced the se

SUBMITTER: Liu AT 

PROVIDER: S-EPMC8624890 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature