Extracellular Matrix Remodeling by Fibroblast-MMP14 Regulates Melanoma Growth.

ABSTRACT: Maintaining a balanced state in remodeling the extracellular matrix is crucial for tissue homeostasis, and this process is altered during skin cancer progression. In melanoma, several proteolytic enzymes are expressed in a time and compartmentalized manner to support tumor progression by generating a permissive environment. One of these proteases is the matrix metalloproteinase 14 (MMP14). We could previously show that deletion of MMP14 in dermal fibroblasts results in the generation of a fibrotic-like skin in which melanoma growth is impaired. That was primarily due to collagen I accumulation due to lack of the collagenolytic activity of MMP14. However, as well as collagen I processing, MMP14 can also process several extracellular matrices. We investigated extracellular matrix alterations

SUBMITTER: Pach E 

PROVIDER: S-EPMC8625044 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature