Antimicrobial Peptides in the Battle against Orthopedic Implant-Related Infections: A Review.

ABSTRACT: Prevention of orthopedic implant-related infections is a major medical challenge, particularly due to the involvement of biofilm-encased and multidrug-resistant bacteria. Current therapies, based on antibiotic administration, have proven to be insufficient, and infection prevalence may rise due to the dissemination of antibiotic resistance. Antimicrobial peptides (AMPs) have attracted attention as promising substitutes of conventional antibiotics, owing to their broad-spectrum of activity, high efficacy at very low concentrations, and, importantly, low propensity for inducing resistance. The aim of this review is to offer an updated perspective of the development of AMPs-based preventive strategies for orthopedic and dental implant-related infections. In this regard, two major research str

SUBMITTER: Costa B 

PROVIDER: S-EPMC8625235 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature