Integrating Porphyrinic Metal-Organic Frameworks in Nanofibrous Carrier for Photodynamic Antimicrobial Application.

ABSTRACT: The rise and spread of antimicrobial resistance is creating an ever greater challenge in wound management. Nanofibrous membranes (NFMs) incorporated with antibiotics have been widely used to remedy bacterial wound infections owing to their versatile features. However, misuse of antibiotics has resulted in drug resistance, and it remains a significant challenge to achieve both high antibacterial efficiency and without causing bacterial resistance. Here, the 'MOF-first' strategy was adopted, the porphyrinic metal-organic frameworks nanoparticles (PCN-224 NPs) were pre-synthesized first, and then the composite antibacterial PCN-224 NPs @ poly (ε-caprolactone) (PM) NFMs were fabricated via a facile co-electrospinning technology. This strategy allows large amounts of effective MOFs to be integr

SUBMITTER: Zhang H 

PROVIDER: S-EPMC8625335 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature