Development of a Hamster Natural Transmission Model of SARS-CoV-2 Infection.

ABSTRACT: The global pandemic of coronavirus disease (COVID-19) caused by infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has led to an international thrust to study pathogenesis and evaluate interventions. Experimental infection of hamsters and the resulting respiratory disease is one of the preferred animal models since clinical signs of disease and virus shedding are similar to more severe cases of human COVID-19. The main route of challenge has been direct inoculation of the virus via the intranasal route. To resemble the natural infection, we designed a bespoke natural transmission cage system to assess whether recipient animals housed in physically separate adjacent cages could become infected from a challenged donor animal in a central cage, with equal airflow acro

SUBMITTER: Dowall S 

PROVIDER: S-EPMC8625437 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature