First DNA Sequencing in Beninese Indigenous Cattle Breeds Captures New Milk Protein Variants.

ABSTRACT: This study investigated polymorphisms in the milk protein genes CSN1S1, CSN2, CSN1S2, CSN3, LALBA, and LGB, and casein haplotypes in Beninese indigenous cattle. Considering 67 animals, DNA sequencing of the genes' exons, flanking regions and parts of the 5'-upstream regions identified 1058 genetic variants including 731 previously unknown. In addition, four novel milk protein variants were detected, including CSN3^K (p.Ala66Val), LALBA^F (p.Arg58Trp), LGB^B1 (p.Ala134Val) and LGB^K (p.Thr92Asnfs*13). CSN3^K is caused by a novel SNP (BTA6:85656526C>T, exon 4) whereas LALBA^F and LGB^B1 are due to rs714688595C>T (exon 1) and rs109625

SUBMITTER: Vanvanhossou SFU 

PROVIDER: S-EPMC8625544 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature