A Maximum Flow-Based Approach to Prioritize Drugs for Drug Repurposing of Chronic Diseases.

ABSTRACT: The discovery of new drugs is required in the time of global aging and increasing populations. Traditional drug development strategies are expensive, time-consuming, and have high risks. Thus, drug repurposing, which treats new/other diseases using existing drugs, has become a very admired tactic. It can also be referred to as the re-investigation of the existing drugs that failed to indicate the usefulness for the new diseases. Previously published literature used maximum flow approaches to identify new drug targets for drug-resistant infectious diseases but not for drug repurposing. Therefore, we are proposing a maximum flow-based protein-protein interactions (PPIs) network analysis approach to identify new drug targets (proteins) from the targets of the FDA (Food and Drug Administration

SUBMITTER: Islam MM 

PROVIDER: S-EPMC8625622 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature