Structural Biology of Nanobodies against the Spike Protein of SARS-CoV-2.

ABSTRACT: Nanobodies are 130 amino acid single-domain antibodies (V_HH) derived from the unique heavy-chain-only subclass of Camelid immunogloblins. Their small molecular size, facile expression, high affinity and stability have combined to make them unique targeting reagents with numerous applications in the biomedical sciences. The first nanobody agent has now entered the clinic as a treatment against a blood disorder. The spread of the SARS-CoV-2 virus has seen the global scientific endeavour work to accelerate the development of technologies to try to defeat a pandemic that has now killed over four million people. In a remarkably short period of time, multiple studies have reported nanobodies directed against the viral Spike protein. Several agents have been tested in culture and demon

SUBMITTER: Tang Q 

PROVIDER: S-EPMC8625641 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature