Toughening mechanisms for the attachment of architectured materials: The mechanics of the tendon enthesis.

ABSTRACT: Architectured materials offer tailored mechanical properties but are limited in engineering applications due to challenges in maintaining toughness across their attachments. The enthesis connects tendon and bone, two vastly different architectured materials, and exhibits toughness across a wide range of loadings. Understanding the mechanisms by which this is achieved could inform the development of engineered attachments. Integrating experiments, simulations, and previously unexplored imaging that enabled simultaneous observation of mineralized and unmineralized tissues, we identified putative mechanisms of enthesis toughening in a mouse model and then manipulated these mechanisms via in vivo control of mineralization and architecture. Imaging uncovered a fibrous architecture within the en

SUBMITTER: Golman M 

PROVIDER: S-EPMC8626067 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature