Implantable system for chronotherapy.
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ABSTRACT:
SUBMITTER: Lee SH
PROVIDER: S-EPMC8626078 | biostudies-literature | 2021 Nov
REPOSITORIES: biostudies-literature
Publications
Implantable system for chronotherapy.
Lee Seung Ho SH Wan Qianqian Q Wentworth Adam A Ballinger Ian I Ishida Keiko K Collins Joy E JE Tamang Siddartha S Huang Hen-Wei HW Li Canchen C Hess Kaitlyn K Lopes Aaron A Kirtane Ameya R AR Lee Jung Seung JS Lee SeJun S Chen Wei W Wong Kaitlyn K Selsing George G Kim Hyunjoon H Buckley Stephen T ST Hayward Alison A Langer Robert R Traverso Giovanni G
Science advances 20211126 48
Diurnal variation in enzymes, hormones, and other biological mediators has long been recognized in mammalian physiology. Developments in pharmacobiology over the past few decades have shown that timing drug delivery can enhance drug efficacy. Here, we report the development of a battery-free, refillable, subcutaneous, and trocar-compatible implantable system that facilitates chronotherapy by enabling tight control over the timing of drug administration in response to external mechanical actuatio ...[more]
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