Low-flow intussusception and metastable VEGFR2 signaling launch angiogenesis in ischemic muscle.
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ABSTRACT:
SUBMITTER: Arpino JM
PROVIDER: S-EPMC8626079 | biostudies-literature | 2021 Nov
REPOSITORIES: biostudies-literature
Publications
Low-flow intussusception and metastable VEGFR2 signaling launch angiogenesis in ischemic muscle.
Arpino John-Michael JM Yin Hao H Prescott Emma K EK Staples Sabrina C R SCR Nong Zengxuan Z Li Fuyan F Chevalier Jacqueline J Balint Brittany B O'Neil Caroline C Mortuza Rokhsana R Milkovich Stephanie S Lee Jason J JJ Lorusso Daniel D Sandig Martin M Hamilton Douglas W DW Holdsworth David W DW Poepping Tamie L TL Ellis Christopher G CG Pickering J Geoffrey JG
Science advances 20211126 48
Efforts to promote sprouting angiogenesis in skeletal muscles of individuals with peripheral artery disease have not been clinically successful. We discovered that, contrary to the prevailing view, angiogenesis following ischemic muscle injury in mice was not driven by endothelial sprouting. Instead, real-time imaging revealed the emergence of wide-caliber, primordial conduits with ultralow flow that rapidly transformed into a hierarchical neocirculation by transluminal bridging and intussuscept ...[more]
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