Thermosensitive receptors in neural stem cells link stress-induced hyperthermia to impaired neurogenesis via microglial engulfment.
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ABSTRACT:
SUBMITTER: Hoshi Y
PROVIDER: S-EPMC8626080 | biostudies-literature | 2021 Nov
REPOSITORIES: biostudies-literature
Publications
Thermosensitive receptors in neural stem cells link stress-induced hyperthermia to impaired neurogenesis via microglial engulfment.
Hoshi Yutaka Y Shibasaki Koji K Gailly Philippe P Ikegaya Yuji Y Koyama Ryuta R
Science advances 20211126 48
Social stress impairs hippocampal neurogenesis and causes psychiatric disorders such as depression. Recent studies have highlighted the significance of increased body temperature in stress responses; however, whether and how social stress–induced hyperthermia affects hippocampal neurogenesis remains unknown. Here, using transgenic mice in which the thermosensitive transient receptor potential vanilloid 4 (TRPV4) is conditionally knocked out in Nestin-expressing neural stem cells (NSCs), we found ...[more]
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