Metabolomic profiling reveals a differential role for hippocampal glutathione reductase in infantile memory formation.

ABSTRACT: The metabolic mechanisms underlying the formation of early-life episodic memories remain poorly characterized. Here, we assessed the metabolomic profile of the rat hippocampus at different developmental ages both at baseline and following episodic learning. We report that the hippocampal metabolome significantly changes over developmental ages and that learning regulates differential arrays of metabolites according to age. The infant hippocampus had the largest number of significant changes following learning, with downregulation of 54 metabolites. Of those, a large proportion was associated with the glutathione-mediated cellular defenses against oxidative stress. Further biochemical, molecular, and behavioral assessments revealed that infantile learning evokes a rapid and persistent incre

SUBMITTER: Bessieres B 

PROVIDER: S-EPMC8626085 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature