Molecularly imprinted polymer based electrochemical sensor for quantitative detection of SARS-CoV-2 spike protein.

ABSTRACT: The continued spread of the coronavirus disease and prevalence of the global pandemic is exacerbated by the increase in the number of asymptomatic individuals who unknowingly spread the SARS-CoV-2 virus. Although remarkable progress is being achieved at curtailing further rampage of the disease, there is still the demand for simple and rapid diagnostic tools for early detection of the COVID-19 infection and the following isolation. We report the fabrication of an electrochemical sensor based on a molecularly imprinted polymer synthetic receptor for the quantitative detection of SARS-CoV-2 spike protein subunit S1 (ncovS1), by harnessing the covalent interaction between 1,2-diols of the highly glycosylated protein and the boronic acid group of 3-aminophenylboronic acid (APBA). The sensor di

SUBMITTER: Ayankojo AG 

PROVIDER: S-EPMC8626155 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature