Antioxidant Effect of Melatonin in Preterm Newborns.

ABSTRACT:

Introduction

Preterm infants are at risk of free radical-mediated diseases from oxidative stress (OS) injury. Increased free radical generation has been demonstrated in preterm infants during the first seven days of life. Melatonin (MEL) is a powerful antioxidant and scavenger of free radicals. In preterm neonates, melatonin deficiency has been reported. Exogenous melatonin administration appears a promising strategy in the treatment of neonatal morbidities in which OS has a leading role.

Objective

The aim was to evaluate plasma MEL concentrations and OS biomarkers in preterm newborns after early administration of melatonin.

Methods

A prospective, randomized double-blind placebo-controlled pilot study was conducted from January 2019 to September 2020. Thirty-six prete

SUBMITTER: Marseglia L 

PROVIDER: S-EPMC8626170 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature