Fat mass and obesity-associated protein regulates RNA methylation associated with depression-like behavior in mice.

ABSTRACT: Post-transcriptional modifications of RNA, such as RNA methylation, can epigenetically regulate behavior, for instance learning and memory. However, it is unclear whether RNA methylation plays a critical role in the pathophysiology of major depression disorder (MDD). Here, we report that expression of the fat mass and obesity associated gene (FTO), an RNA demethylase, is downregulated in the hippocampus of patients with MDD and mouse models of depression. Suppressing Fto expression in the mouse hippocampus results in depression-like behaviors in adult mice, whereas overexpression of FTO expression leads to rescue of the depression-like phenotype. Epitranscriptomic profiling of N6-methyladenosine (m⁶A) RNA methylation in the hippocampus of Fto knockdown (KD), Fto knockout (cKO),

SUBMITTER: Liu S 

PROVIDER: S-EPMC8626436 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature