Traumatic brain injury in the presence of Aβ pathology affects neuronal survival, glial activation and autophagy.

ABSTRACT: Traumatic brain injury (TBI) presents a widespread health problem in the elderly population. In addition to the acute injury, epidemiological studies have observed an increased probability and earlier onset of dementias in the elderly following TBI. However, the underlying mechanisms of the connection between TBI and Alzheimer's disease in the aged brain and potential exacerbating factors is still evolving. The aim of this study was to investigate cellular injury-induced processes in the presence of amyloid β (Aβ) pathology. For this purpose, a co-culture system of cortical stem-cell derived astrocytes, neurons and oligodendrocytes were exposed to Aβ₄₂ protofibrils prior to a mechanically induced scratch injury. Cellular responses, including neurodegeneration, glial activation a

SUBMITTER: Streubel-Gallasch L 

PROVIDER: S-EPMC8626479 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature