Metronomic chemotherapy with cyclophosphamide for the treatment of advanced hepatocellular cancer: A case report.

ABSTRACT:

Introduction and importance

Metronomic chemotherapy entails chronic, equally spaced administration of low doses of various chemotherapeutic drugs without extended rest periods. Its use as a second-line treatment in advanced or metastatic hepatocellular cancer remains under investigation.

Case presentation

We report a case of a 49-year-old Caucasian female patient with an enlarged (∼14 cm) hepatocellular cancer. In July 2016, she underwent right hepatectomy (after preceding TACE). During the follow-up period, she presented early disease recurrence with lung and peritoneal metastasis. Initially, she received an inhibitor of protein kinase (sorafenib) for six months without response. Afterwards, cyclophosphamide administration at low doses as metronomic chemotherapy provided co

SUBMITTER: Peristeri DV 

PROVIDER: S-EPMC8626568 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature