P.G12C KRAS mutation prevalence in non-small cell lung cancer: Contribution from interregional variability and population substructures among Hispanics.

ABSTRACT:

Background

The KRAS exon 2 p. G12C mutation in patients with lung adenocarcinoma has been increasing in relevance due to the development and effectiveness of new treatment medications. Studies around different populations indicate that regional variability between ethnic groups and ancestries could play an essential role in developing this molecular alteration within lung cancer.

Methods

In a prospective and retrospective cohort study on samples from lung adenocarcinoma from 1000 patients from different administrative regions in Colombia were tested for the KRAS p.G12C mutation. An analysis of STR populations markers was conducted to identify substructure contributions to mutation prevalence.

Results

Included were 979 patients with a national mean frequency for the KR

SUBMITTER: Ruiz-Patino A 

PROVIDER: S-EPMC8626684 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature