Optimizing high-flow nasal cannula flow settings in adult hypoxemic patients based on peak inspiratory flow during tidal breathing.

ABSTRACT:

Background

Optimal flow settings during high-flow nasal cannula (HFNC) therapy are unknown. We investigated the optimal flow settings during HFNC therapy based on breathing pattern and tidal inspiratory flows in patients with acute hypoxemic respiratory failure (AHRF).

Methods

We conducted a prospective clinical study in adult hypoxemic patients treated by HFNC with a fraction of inspired oxygen (F_IO₂) ≥ 0.4. Patient's peak tidal inspiratory flow (PTIF) was measured and HFNC flows were set to match individual PTIF and then increased by 10 L/min every 5-10 min up to 60 L/min. F_IO₂ was titrated to maintain pulse oximetry (SpO₂) of 90-97%. SpO₂/F_IO₂, respiratory rate (RR), ROX index [(SpO

SUBMITTER: Li J 

PROVIDER: S-EPMC8626729 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature