A Retinoic Acid Receptor β ₂ Agonist Improves Cardiac Function in a Heart Failure Model.

ABSTRACT: We previously demonstrated that the selective retinoic acid receptor (RAR) β ₂ agonist AC261066 reduces oxidative stress in an ex vivo murine model of ischemia/reperfusion. We hypothesized that by decreasing oxidative stress and consequent fibrogenesis, AC261066 could attenuate the development of contractile dysfunction in post-ischemic heart failure (HF). We tested this hypothesis in vivo using an established murine model of myocardial infarction (MI), obtained by permanent occlusion of the left anterior descending coronary artery. Treating mice with AC261066 in drinking water significantly attenuated the post-MI deterioration of echocardiographic indices of cardiac function, diminished remodeling, and reduced oxidative stress, as evidenced by a decrease in malondialdehy

SUBMITTER: Tang XH 

PROVIDER: S-EPMC8626778 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature