Temporality of clinical factors associated with pancreatic cancer: a case-control study using linked electronic health records.

ABSTRACT:

Background

Pancreatic cancer risk is poorly quantified in relation to the temporal presentation of medical comorbidities and lifestyle. This study aimed to examine this aspect, with possible influence of demographics.

Methods

We conducted a retrospective case-control study on the ethnically-diverse population of East London, UK, using linked electronic health records. We evaluated the independent and two-way interaction effects of 19 clinico-demographic factors in patients with pancreatic cancer (N = 965), compared with non-malignant pancreatic conditions (N = 3963) or hernia (control; N = 4355), reported between April 1, 2008 and March 6, 2020. Risks were quantified by odds ratios (ORs) and 95% confidence intervals (CIs) from multivariable logistic regression models.

Res

SUBMITTER: Dayem Ullah AZM 

PROVIDER: S-EPMC8626898 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature