A multicenter randomized placebo-controlled trial of intravenous thyroxine for heart-eligible brain-dead organ donors.

ABSTRACT:

Background

Brain death frequently induces hemodynamic instability and cardiac stunning. Impairments in cardiac performance are major contributors to hearts from otherwise eligible organ donors not being transplanted. Deficiencies in pituitary hormones (including thyroid-stimulating hormone) may contribute to hemodynamic instability, and replacement of thyroid hormone has been proposed as a means of improving stability and increasing hearts available for transplantation. Intravenous thyroxine is commonly used in donor management. However, small controlled trials have not been able to demonstrate efficacy.

Methods

This multicenter study will involve organ procurement organizations (OPOs) across the country. A total of 800 heart-eligible brain-dead organ donors who require vaso

SUBMITTER: Dhar R 

PROVIDER: S-EPMC8626969 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature