Dysregulation of alternative splicing is associated with the pathogenesis of ulcerative colitis.

ABSTRACT:

Background

Although numerous risk loci for ulcerative colitis (UC) have been identified in the human genome, the pathogenesis of UC remains unclear. Recently, multiple transcriptomic analyses have shown that aberrant gene expression in the colon tissues of UC patients is associated with disease progression. A pioneering study also demonstrated that altered post-transcriptional regulation is involved in the progression of UC. Here, we provide a genome-wide analysis of alternative splicing (AS) signatures in UC patients. We analyzed three datasets containing 74 tissue samples from UC patients and identified over 2000 significant AS events.

Results

Skipped exon and alternative first exon were the two most significantly altered AS events in UC patients. The immune response-relat

SUBMITTER: Li D 

PROVIDER: S-EPMC8627048 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature