Prognostic role of METTL1 in glioma.

ABSTRACT:

Background

Current treatment options for glioma are limited, and the prognosis of patients with glioma is poor as the available drugs show low therapeutic efficacy. Furthermore, the molecular mechanisms associated with glioma remain poorly understood. METTL1 mainly catalyzes the formation of N(7)-methylguanine at position 46 of the transfer RNA sequence, thereby regulating the translation process. However, the role of METTL1 in glioma has not been studied to date. The purpose of this study was to analyze the expression and prognosis of METTL1 in glioma, and to explore the potential analysis mechanism.

Methods

Data from five publicly available databases were used to analyze METTL1 expression across different tumor types and its differential expression between carcinoma and ad

SUBMITTER: Li L 

PROVIDER: S-EPMC8627054 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature