Quantitative multiparametric MRI predicts response to neoadjuvant therapy in the community setting.

ABSTRACT:

Background

The purpose of this study was to determine whether advanced quantitative magnetic resonance imaging (MRI) can be deployed outside of large, research-oriented academic hospitals and into community care settings to predict eventual pathological complete response (pCR) to neoadjuvant therapy (NAT) in patients with locally advanced breast cancer.

Methods

Patients with stage II/III breast cancer (N = 28) were enrolled in a multicenter study performed in community radiology settings. Dynamic contrast-enhanced (DCE) and diffusion-weighted (DW)-MRI data were acquired at four time points during the course of NAT. Estimates of the vascular perfusion and permeability, as assessed by the volume transfer rate (K^trans) using the Patlak model, were generated from the

SUBMITTER: Virostko J 

PROVIDER: S-EPMC8627106 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature