Comparing efficacy and safety of different doses of dexamethasone in the treatment of COVID-19: a three-arm randomized clinical trial.

ABSTRACT:

Background and objectives

Corticosteroids are commonly used in the treatment of hospitalized patients with COVID-19. The goals of the present study were to compare the efficacy and safety of different doses of dexamethasone in the treatment of patients with a diagnosis of moderate to severe COVID-19.

Methods

Hospitalized patients with a diagnosis of moderate to severe COVID-19 were assigned to intravenous low-dose (8 mg once daily), intermediate-dose (8 mg twice daily) or high-dose (8 mg thrice daily) dexamethasone for up to 10 days or until hospital discharge. Clinical response, 60-day survival and adverse effects were the main outcomes of the study.

Results

In the competing risk survival analysis, patients in the low-dose group had a higher clinical response than th

SUBMITTER: Toroghi N 

PROVIDER: S-EPMC8627167 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature