RNA N⁶-methyladenosine modification in solid tumors: new therapeutic frontiers.

ABSTRACT: Epigenetic mRNA modification is an evolving field. N⁶-methyladenosine (m⁶A) is the most frequent internal transcriptional modification in eukaryotic messenger RNAs (mRNAs). This review will discuss the functions of the m⁶A mRNA machinery, including its "writers" that are components of the methyltransferase complex, its "readers" and its "erasers" (specifically FTO and ALKBH5) in cancer. The writers deposit the m⁶A and include METTL3, METTL14, WTAP, VIRMA, and RBM15. M⁶A methylation is removed by the m6A demethylases (FTO and ALKBH5). Lastly, the most diverse members are the readers that can contribute to mRNA splicing, stability, translation, and nuclear export. Many of these functions continue to be elucidated. The dysregulation of th

SUBMITTER: Melstrom L 

PROVIDER: S-EPMC8627172 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature