Third generation cephalosporin resistance in clinical non-typhoidal Salmonella enterica in Germany and emergence of bla_CTX-M-harbouring pESI plasmids.

ABSTRACT: Non-typhoidal Salmonella enterica is an important gastrointestinal pathogen causing a considerable burden of disease. Resistance to third generation cephalosporins poses a serious threat for treatment of severe infections. In this study occurrence, phylogenetic relationship, and mechanisms of third generation cephalosporin resistance were investigated for clinical non-typhoidal S. enterica isolates in Germany. From 2017 to 2019, we detected 168 unique clinical S. enterica isolates with phenotypic resistance to third generation cephalosporins in a nation-wide surveillance. Compared to previous years, we observed a significant (P=0.0002) and consistent increase in resistant isolates from 0.41 % in 2005 to 1.71 % in 2019. In total, 34 different serovars were identi

SUBMITTER: Pietsch M 

PROVIDER: S-EPMC8627203 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature