Cross-sectional study comparing cognitive function in treatment responsive versus treatment non-responsive schizophrenia: evidence from the STRATA study.

ABSTRACT:

Background

70%-84% of individuals with antipsychotic treatment resistance show non-response from the first episode. Emerging cross-sectional evidence comparing cognitive profiles in treatment resistant schizophrenia to treatment-responsive schizophrenia has indicated that verbal memory and language functions may be more impaired in treatment resistance. We sought to confirm this finding by comparing cognitive performance between antipsychotic non-responders (NR) and responders (R) using a brief cognitive battery for schizophrenia, with a primary focus on verbal tasks compared against other measures of cognition.

Design

Cross-sectional.

Setting

This cross-sectional study recruited antipsychotic treatment R and antipsychotic NR across four UK sites. Cognitive performanc

SUBMITTER: Millgate E 

PROVIDER: S-EPMC8627394 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature